Clonidine-induced body temperature changes in rats with anterior or posterior cortical damage
نویسندگان
چکیده
Animals with anterior or posterior neocortical lesions as well as intact control animals were evaluated for changes in a-adrenergic sensitivity at five postoperative times. Colonic temperature decreases were measured in response to clonidine at each of the postoperative periods. The result indicated that a heightened heat-loss response was induced by clonidine that lasted 21 or more days after destruction of the posterior neocortex. This exaggerated response to the drug was not found in animals with anterior neocortical lesions.
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